Practitioners

Clinical RESULTS are the difference! We don’t know of any glucosamine and or chondroitin trial that came close to achieving the results as seen in the trial below.

This study was awarded first Prize out of the 90 papers presented at the Scripps conference in San Diego.

The capsules were tested with 93 people with knee issues; 47 received Active Again cetylated oils and 46 received Placebo capsules.

After just 2 weeks the Active Again group were able to walk an additional 232 feet

• After 4 weeks the Active Again group were able to walk an additional 330 feet 
• After 8 weeks the Active Again group were able to walk an additional 537 feet
• The placebo group DID NOT IMPROVE!

We don’t know of any glucosamine or omega 3 research trial that showed such a dramatic difference when compared to placebo.

In 1994 Dr. Kim Vanderlinden the founder of Hope Science introduced glucosamine, and helped to create the “Joint Health” market. The original and US patented glucosamine was from an Italian company called Rotta. Some of Rotta’s research showed that their glucosamine helped somewhat. Unfortunately to get around the patent, other forms of glucosamine were marketed and so efficacy and clinical credibility are real concerns. 

In 2006 through to 2008 the largest and most rigorous investigation ever of glucosamine and chondroitin was conducted. 

The study cost over 12 million dollars and was funded by the National Institute for Health or NIH.

GAIT 2006 & 2008 Glucosamine Arthritis Intervention Trial

New England Journal of Medicine 2006: Volume 354:795-808

The study tested whether glucosamine and chondroitin used separately or in combination reduced pain in participants with knee osteoarthritis (OA). There were a total of 10 groups. Participants were randomly assigned to one of 5 treatment groups for mild OA pain or 5 groups for moderate-to-severe OA pain : 

• glucosamine alone
• chondroitin sulfate alone
• glucosamine and chondroitin sulfate in combination
• celecoxib
• placebo

 Key Results, Researchers found that:

- Overall, there were no significant differences between the glucosamine and/or chondroitin and placebo.

• For 5 of the 6 treatment groups, no advantage over placebo occurred with glucosamine and chondroitin alone or in combination. For a small subset of participants with moderate-to-severe pain, glucosamine combined with chondroitin provided statistically significant pain relief -about 79 percent had a 20 percent or greater reduction in pain versus about 54 percent for placebo. According to the researchers, because of the small size of this subgroup these findings should be considered preliminary and need to be confirmed in further studies. (group size: 72 patients or less than 5% out of the 1583 patients) 
• Some of the companies selling glucosamine and or chondroitin have referred to the benefit shown to the 5% of study participants, without mentioning it was only 5% and fail to mention the results of the other 95% of study participants. … this can be considered misleading.

 Journal of Arthritis & Rheumatism October 2008 

To study whether glucosamine and/or chondroitin could affect knee cartilage and diminish the structural damage of osteoarthritis, interested GAIT patients were offered the opportunity to continue their original study treatment in the ancillary trial for an additional 18 months, for a total of two years. A total of 572 of the original 1583 continued on.

 Key Results, Researchers found that:

- The dietary supplements glucosamine and chondroitin sulfate, together or alone, appeared to fare no better than placebo in slowing loss of cartilage, researchers from the Glucosamine/chondroitin Arthritis Intervention Trial (GAIT) team report in the October issue of Arthritis & Rheumatism

- Glucosamine plus chondroitin had slightly MORE cartilage loss than placebo. The results were .194 millimeters loss of cartilage for glucosamine combined with chondroitin versus .166 millimeters for the placebo group. This is a small difference and not statistically significant, but certainly not a benefit!

PROOF?

Did you know that some companies selling glucosamine refer specifically to the GAIT study as “proof” that glucosamine and chondroitin work? This is amazing when one realizes that less than 5% of the study participants experienced more pain relief after 6 months than those on placebo. It is even more amazing when one realizes that there was no benefit to the cartilage after 2 years.

We encourage practitioners to review the published research.

The Cochrane Collaboration’s review of Glucosamine includes 20 studies with 2570 patients.

WOMAC outcomes of pain, stiffness and function did not show a superiority of glucosamine over placebo for both Rotta and non-Rotta preparations of glucosamine. Glucosamine was as safe as placebo. See the review in the research section.

Absolutely, we welcome the opportunity to introduce you to Active Again.

Our team can explain the product range, provide access to available research and discuss our professional purchasing program.

Call 1-866-NATURAL (628-8725) to learn more.

Contact Hope Science at 1-866-NATURAL (628-8725).

Our team can explain professional purchasing opportunities and help you get started.